The University of Karachi, informally called Karachi University or is a public research university located in Karachi.

With a total student body of 41,000 full-time students and a campus size spanning over 1200 acres, Karachi University is one of the largest university in Pakistan with a distinguished reputation for multi-disciplinary research in science and technology, medical, and social sciences. The university has over 53 Departments and 19 research institutes operating under nine faculties. There are over 893 academics and more than 2500 supporting staff working for the university.

In 2008, the university was named for the first time by THE-QS World University Rankings for the top 600 universities in the world. During 2009, the university was named by now defunct THE-QS World University Rankings for the top 500 universities in the world, while it is ranked by QS World University Rankings in 2016 as among to the top 250 in Asia and among 701st in the world. In 2019 it was ranked 801st in the world and 251 in Asia. The university is a member of Association of Commonwealth Universities of the United Kingdom.